I was doing some research for my latest online writing job when I stumbled on this video posted on YouTube. I have seen movies and known acquaintances to have obsessive-compulsive disorders but this my first time to see the condition reach into gargantuan proportions in ruining a person's life in terms of losing his job and relationships.
This prompted me to write something about the disorder. The article stresses on self-assessment whether you have OCD or will likely to have OCD. Knowing that you might have the disorder, the soonest way possible, can be very helpful in finding ways to manage the ritualistic behaviors.
A new study linking smoking to Alzheimer's disease was published yesterday in the online edition of Archives of Internal Medicine. Researchers said that the study has proved that those who smoke during their middle ages increases their risk to develop Alzheimer's by 157%.
The study was conducted over 21,123 ethnically diverse people, between the ages of 50 and 60 years old covering the years between 1978 and 1985. During an average follow-up of 23 years, the researchers found that 25.4 percent were diagnosed with dementia, including Alzheimer's (1,136 people) or vascular dementia (416 people). Most of the people who developed Alzheimer's were heavy smokers, i.e., smoking of more than two cigarette packs a day.
Since this was conducted through observation, the exact mechanism on how smoking may contribute to the development of Alzheimer's was not fully elaborated. Researchers believed that it is similar to stroke or the formation of clots wherein oxidative process takes place and oxygenation or tissue perfusion of the brain cells is compromised. In due time, the neurons, which are responsible for transmitting electrical impulses for neural communication, will be damaged.
Primarily, Alzheimer's is highly known to have genetic influence. This research will have a turnabout on how the public and health providers can prevent the onset of the disease among our seniors because of the modifiability factor of the behavior.
Alzheimer’s disease is likened to a thief at night – quietly sneaking inside our abode while we doze off to dreamland and robbing off our priced possessions without our knowledge.
Alzheimer’s disease is a progressive brain disorder that has a gradual onset, mostly undetected at first since the condition is marked with memory loss that is linked from the so-called senior moments typical of normal aging. As the disease progress, it causes an increasing decline in functioning, including loss of speech, loss of motor function, and profound personality and behavioral changes. The person with Alzheimer’s has been observed to display paranoia, delusions, hallucinations, inattention to hygiene, and belligerence.
After its discovery more than a century ago, no cure has been discovered to stop this memory-robbing disease. There isn’t even a definitive test to identify the disease in its early stages. As a matter of fact, the only way to diagnose a person with Alzheimer’s is after performing an autopsy of brain tissue to examine its hallmark lesions – atrophy of cerebral neurons, senile plaque deposits, and enlargement of the third and fourth ventricles of the brain.
For so many years, the attempts to curtail its tracks had left scientists in frustration and despair. In 2002, a promising vaccine was tested, but instead of protecting the brain from the deleterious effect of Alzheimer’s, it even caused dangerous inflammation in the brain and spinal column and had to be abandoned after years of research. Last August of this year, a highly anticipated drug worsened rather than improved cognitive symptoms.
So, are we losing the fight against this much feared condition among our senior citizens? Has medical science surrendered in finding the cure or even protecting those at risk to develop Alzheimer’s? Time magazine has described that research on finding the drug to cure Alzheimer’s is the cold fusion of medical research: everyone agrees it would be great, and everyone who tries it fails.
Wanted: Amyloid, ApoE4, and Tau
To fully understand how this condition can easily wipe out stored precious memories created over a lifetime, it is better to identify the main players, or so to speak, the thieves behind the crime.
Just like other degenerative disorders, Alzheimer’s has a genetic component. Research has shown linkages to chromosomes 21, 14, and 19 (APA, 2000). The disease is caused by buildup of protein-based plaques in the brain identified as amyloid. What triggered the research community to know more about these protein-plaques is that amyloid in living patients does not necessarily indicate the disease. Is there more to this than meets the eye?
Investigators are working very hard to identify additional sources of the plaque formation. They came up with apolipoprotein E (ApoE), which in certain forms can promote the formation of amyloid. In addition to this, a neural protein known as tau, which stabilizes axons, was also implicated to the process of amyloid build-up.
Putting all of these components together, researchers have traced how neurons gradually die among Alzheimer’s patients:
·Amyloid initially forms as amyloid precursor protein (APP)
Enzymes break APP into short fragments.
The fragments clump together, forming plaques.
Once plaques form, tau, may start to break down.
When tau no longer stabilizes the axons, the neuron shrivels and dies, leaving behind its tangled carcass.
As the neural debris accumulates, the immune system’s inflammatory response is then activated to remove it. In time, this will develop to neural connection shutdown that leads to a drop in cognitive function.
Setting up the Alarm
One way to catch a thief is to set up a security alarm. But this is not a piece of cake for the medical researchers in stopping Alzheimer’s from snuffing out the essence of the affected person. Drugs that were designed to target amyloid plaques affect other processes in the body too, including those that regulate how cells communicate as well as the development of heart, pancreas, and immune system cells. In addition, when scientists examined the autopsied brains of patients in the failed vaccine, they noted that the subjects had fewer plaques than before they received the vaccine but still had shown no improvement on tests of mental function.
With these futile steps, the old adage “an ounce of prevention is better than a pound of cure” may have lost its significance in dealing with persons at risk to develop Alzheimer’s. Nevertheless, a glimmer of hope is still on the horizon. In 2004, the U.S. National Institute on Aging (NIA) partnered with pharmaceutical companies to create the Alzheimer’s Disease Neuroimaging Initiative, a $60 million project tasked to identify between Alzheimer’s patients and unaffected individuals. Once identified, the persons at risk may be tested with drugs whose brains are just beginning to accumulate amyloid.
Lessons Learned
Optimism to treat the disease is still present. From the mistakes committed in the past, experts are now holding two essential lessons that empower the future of Alzheimer’s research:
Timing. It is crucial to treat Alzheimer’s patients as early as possible, perhaps even before they show signs of memory loss or cognitive decline, rather than attempt to improve a brain already scourged by the disease.
Scope of medical assault. Adopting a multipronged approach that address as many of the disease’s complex abnormalities as possible may improve the chances that new therapies used early on will not only delay symptoms but also reverse them.
The recent rumor that Kim Anderson attempted suicide post-Gerald Anderson relationship caught my attention, not because I'm a fan of them, but because of the escalating cases of suicide attempts and suicide incidents among our teenagers.
Several weeks ago, TV Patrol reported of a 13 year old boy who undauntedly took his life after his father scolded him in front of his friends. Overseas, several news about teenagers taking their lives because of cyber bullying is the center of debate among parents, schools, and the government on how to control such malicious online behavior (though I think the real issue here is who to blame?)
Suicide is the intentional killing of oneself. Reasons why teenagers easily kill themselves may have change through the years. Factors such as lack of parental presence and guidance, substance abuse and alcoholism, peer pressure and acceptance, poverty, depression and hopelessness from a recent loss or problems encountered by the adolescent were identified as the major contributors to suicide among teenagers. Recently, availability and accessibility to firearms and cyberbullying are added to the long list of causes.
From this point of view, the internet is the most cruel way of putting the teenager in a compromised position - to face the shame or end one's life.
Suicidal ideations, are also common among teenagers. This means thinking about killing oneself and should not be neglected. This is actually a prelim to what the person is capable of doing. Active suicidal ideation is when the person thinks about and finds way to commit suicide while passive suicidal ideation is when a person thinks about wanting to die or wishes he or she were dead but has no plans to cause his or her death. Of course, active ideations are more considered fatal and must be given close attention.
We may encounter persons expressing to end their lives, as a joke or with sense of hopelessness after a crisis situation. Either way, in the perspective of psychiatry, these are serious conditions. Men are more successful in committing the act and the methods they use are more graver than women. Statistics on women attempting suicide is higher compared to men, since women are naturally fickle-minded, so to speak.
Although the act is intentional, suicide involves ambivalence. Everybody thinks that there's no way to help a person who has plans of killing him or herself and that once a suicide risk, is always a suicide risk are actually myths that the public are constantly misinformed. The ambivalence that these individuals feel during their depressed moments often prompts the cries for help evident in overt and covert cues. This is the correct time to reach out to them and find help form situational supports, choose to live, learn new ways to cope, and move forward in life.
Teenage life is the most crucial phase of a person's growth and development. This is the crossroad where innocence and maturity are intertwined. With the changes in their physical appearance, the need to be identified and acknowledged in a group is a very significant milestone that needs to be achieved. The presence of a supportive parent, welcoming friends and other support help can help lessen the tendencies of teenagers in committing suicide.
